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Thermostabilization of the β(1)-adrenergic receptor Correlates with Increased Entropy of the Inactive State

The dynamic nature of GPCRs is a major hurdle in their purification and crystallization, but thermostabilization can facilitate structure determination, as has been shown by the structure of the thermostabilized β(1)-adrenergic receptor (β(1)AR) mutant, m23-β(1)AR, which has been thermostabilized in...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Niesen, Michiel JM, Bhattacharya, Supriyo, Grisshammer, Reinhard, Tate, Christopher G, Vaidehi, Nagarajan
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2013
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3718486/
https://ncbi.nlm.nih.gov/pubmed/23697892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp403207c
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