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Thermostabilization of the β(1)-adrenergic receptor Correlates with Increased Entropy of the Inactive State
The dynamic nature of GPCRs is a major hurdle in their purification and crystallization, but thermostabilization can facilitate structure determination, as has been shown by the structure of the thermostabilized β(1)-adrenergic receptor (β(1)AR) mutant, m23-β(1)AR, which has been thermostabilized in...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3718486/ https://ncbi.nlm.nih.gov/pubmed/23697892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp403207c |
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