PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal

The adrenal cortex undergoes remodeling during fetal and postnatal life. How zona reticularis emerges in the postnatal gland to support adrenarche, a process whereby higher primates increase prepubertal androgen secretion, is unknown. Using cell-fate mapping and gene deletion studies in mice, we sho...

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Udgivet i:JCI Insight
Main Authors: Dumontet, Typhanie, Sahut-Barnola, Isabelle, Septier, Amandine, Montanier, Nathanaëlle, Plotton, Ingrid, Roucher-Boulez, Florence, Ducros, Véronique, Lefrançois-Martinez, Anne-Marie, Pointud, Jean-Christophe, Zubair, Mohamad, Morohashi, Ken-Ichirou, Breault, David T., Val, Pierre, Martinez, Antoine
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821213/
https://ncbi.nlm.nih.gov/pubmed/29367455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.98394
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