PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal

The adrenal cortex undergoes remodeling during fetal and postnatal life. How zona reticularis emerges in the postnatal gland to support adrenarche, a process whereby higher primates increase prepubertal androgen secretion, is unknown. Using cell-fate mapping and gene deletion studies in mice, we sho...

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Publicado en:JCI Insight
Autores principales: Dumontet, Typhanie, Sahut-Barnola, Isabelle, Septier, Amandine, Montanier, Nathanaëlle, Plotton, Ingrid, Roucher-Boulez, Florence, Ducros, Véronique, Lefrançois-Martinez, Anne-Marie, Pointud, Jean-Christophe, Zubair, Mohamad, Morohashi, Ken-Ichirou, Breault, David T., Val, Pierre, Martinez, Antoine
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2018
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821213/
https://ncbi.nlm.nih.gov/pubmed/29367455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.98394
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