mTOR pathway is activated by PKA in adrenocortical cells and participates in vivo to apoptosis resistance in primary pigmented nodular adrenocortical disease (PPNAD)

Primary pigmented nodular adrenocortical disease (PPNAD) is associated with inactivating mutations of the PRKAR1A tumor suppressor gene that encodes the regulatory subunit R1α of the cAMP-dependent protein kinase (PKA). In human and mouse adrenocortical cells, these mutations lead to increased PKA a...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: de Joussineau, Cyrille, Sahut-Barnola, Isabelle, Tissier, Frédérique, Dumontet, Typhanie, Drelon, Coralie, Batisse-Lignier, Marie, Tauveron, Igor, Pointud, Jean-Christophe, Lefrançois-Martinez, Anne-Marie, Stratakis, Constantine A., Bertherat, Jérôme, Val, Pierre, Martinez, Antoine
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
Soggetti:
Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4184389/
https://ncbi.nlm.nih.gov/pubmed/24865460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu265
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi