mTOR pathway is activated by PKA in adrenocortical cells and participates in vivo to apoptosis resistance in primary pigmented nodular adrenocortical disease (PPNAD)

Primary pigmented nodular adrenocortical disease (PPNAD) is associated with inactivating mutations of the PRKAR1A tumor suppressor gene that encodes the regulatory subunit R1α of the cAMP-dependent protein kinase (PKA). In human and mouse adrenocortical cells, these mutations lead to increased PKA a...

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主要な著者: de Joussineau, Cyrille, Sahut-Barnola, Isabelle, Tissier, Frédérique, Dumontet, Typhanie, Drelon, Coralie, Batisse-Lignier, Marie, Tauveron, Igor, Pointud, Jean-Christophe, Lefrançois-Martinez, Anne-Marie, Stratakis, Constantine A., Bertherat, Jérôme, Val, Pierre, Martinez, Antoine
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2014
主題:
Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4184389/
https://ncbi.nlm.nih.gov/pubmed/24865460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu265
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