mTOR pathway is activated by PKA in adrenocortical cells and participates in vivo to apoptosis resistance in primary pigmented nodular adrenocortical disease (PPNAD)

Primary pigmented nodular adrenocortical disease (PPNAD) is associated with inactivating mutations of the PRKAR1A tumor suppressor gene that encodes the regulatory subunit R1α of the cAMP-dependent protein kinase (PKA). In human and mouse adrenocortical cells, these mutations lead to increased PKA a...

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Main Authors: de Joussineau, Cyrille, Sahut-Barnola, Isabelle, Tissier, Frédérique, Dumontet, Typhanie, Drelon, Coralie, Batisse-Lignier, Marie, Tauveron, Igor, Pointud, Jean-Christophe, Lefrançois-Martinez, Anne-Marie, Stratakis, Constantine A., Bertherat, Jérôme, Val, Pierre, Martinez, Antoine
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4184389/
https://ncbi.nlm.nih.gov/pubmed/24865460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu265
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