EZH2 cooperates with E2F1 to stimulate expression of genes involved in adrenocortical carcinoma aggressiveness

BACKGROUND: EZH2 is overexpressed and associated with poor prognosis in adrenocortical carcinoma (ACC) and its inhibition reduces growth and aggressiveness of ACC cells in culture. Although EZH2 was identified as the methyltransferase that deposits the repressive H3K27me3 histone mark, it can cooper...

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Bibliografiske detaljer
Udgivet i:Br J Cancer
Main Authors: Tabbal, Houda, Septier, Amandine, Mathieu, Mickael, Drelon, Coralie, Rodriguez, Stéphanie, Djari, Cyril, Batisse-Lignier, Marie, Tauveron, Igor, Pointud, Jean-Christophe, Sahut-Barnola, Isabelle, Ragazzon, Bruno, Assié, Guillaume, Bertherat, Jérôme, Lefrançois-Martinez, Anne-Marie, Martinez, Antoine, Val, Pierre
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6738105/
https://ncbi.nlm.nih.gov/pubmed/31363169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-019-0538-y
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