EZH2 cooperates with E2F1 to stimulate expression of genes involved in adrenocortical carcinoma aggressiveness

BACKGROUND: EZH2 is overexpressed and associated with poor prognosis in adrenocortical carcinoma (ACC) and its inhibition reduces growth and aggressiveness of ACC cells in culture. Although EZH2 was identified as the methyltransferase that deposits the repressive H3K27me3 histone mark, it can cooper...

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Bibliografski detalji
Izdano u:Br J Cancer
Glavni autori: Tabbal, Houda, Septier, Amandine, Mathieu, Mickael, Drelon, Coralie, Rodriguez, Stéphanie, Djari, Cyril, Batisse-Lignier, Marie, Tauveron, Igor, Pointud, Jean-Christophe, Sahut-Barnola, Isabelle, Ragazzon, Bruno, Assié, Guillaume, Bertherat, Jérôme, Lefrançois-Martinez, Anne-Marie, Martinez, Antoine, Val, Pierre
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6738105/
https://ncbi.nlm.nih.gov/pubmed/31363169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-019-0538-y
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