PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development

Adrenal cortex physiology relies on functional zonation, essential for production of aldosterone by outer zona glomerulosa (ZG) and glucocorticoids by inner zona fasciculata (ZF). The cortex undergoes constant cell renewal, involving recruitment of subcapsular progenitors to ZG fate and subsequent l...

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Publicado no:Nat Commun
Main Authors: Drelon, Coralie, Berthon, Annabel, Sahut-Barnola, Isabelle, Mathieu, Mickaël, Dumontet, Typhanie, Rodriguez, Stéphanie, Batisse-Lignier, Marie, Tabbal, Houda, Tauveron, Igor, Lefrançois-Martinez, Anne-Marie, Pointud, Jean-Christophe, Gomez-Sanchez, Celso E., Vainio, Seppo, Shan, Jingdong, Sacco, Sonia, Schedl, Andreas, Stratakis, Constantine A., Martinez, Antoine, Val, Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027289/
https://ncbi.nlm.nih.gov/pubmed/27624192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12751
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