Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance

Immune checkpoint blockade produces clinical benefit in many patients. However better biomarkers of response are still needed, and mechanisms of resistance remain incompletely understood. To address this, we recently studied a cohort of melanoma patients treated with sequential checkpoint blockade a...

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Publicado no:Sci Transl Med
Main Authors: Roh, Whijae, Chen, Pei-Ling, Reuben, Alexandre, Spencer, Christine N., Prieto, Peter A., Miller, John P., Gopalakrishnan, Vancheswaran, Wang, Feng, Cooper, Zachary A., Reddy, Sangeetha M., Gumbs, Curtis, Little, Latasha, Chang, Qing, Chen, Wei-Shen, Wani, Khalida, Petaccia De Macedo, Mariana, Chen, Eveline, Austin-Breneman, Jacob L., Jiang, Hong, Roszik, Jason, Tetzlaff, Michael T., Davies, Michael A., Gershenwald, Jeffrey E., Tawbi, Hussein, Lazar, Alexander J., Hwu, Patrick, Hwu, Wen-Jen, Diab, Adi, Glitza, Isabella C., Patel, Sapna P., Woodman, Scott E., Amaria, Rodabe N., Prieto, Victor G., Hu, Jianhua, Sharma, Padmanee, Allison, James P., Chin, Lynda, Zhang, Jianhua, Wargo, Jennifer A., Futreal, P. Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5819607/
https://ncbi.nlm.nih.gov/pubmed/28251903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aah3560
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