Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance

Immune checkpoint blockade produces clinical benefit in many patients. However better biomarkers of response are still needed, and mechanisms of resistance remain incompletely understood. To address this, we recently studied a cohort of melanoma patients treated with sequential checkpoint blockade a...

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Publicat a:Sci Transl Med
Autors principals: Roh, Whijae, Chen, Pei-Ling, Reuben, Alexandre, Spencer, Christine N., Prieto, Peter A., Miller, John P., Gopalakrishnan, Vancheswaran, Wang, Feng, Cooper, Zachary A., Reddy, Sangeetha M., Gumbs, Curtis, Little, Latasha, Chang, Qing, Chen, Wei-Shen, Wani, Khalida, Petaccia De Macedo, Mariana, Chen, Eveline, Austin-Breneman, Jacob L., Jiang, Hong, Roszik, Jason, Tetzlaff, Michael T., Davies, Michael A., Gershenwald, Jeffrey E., Tawbi, Hussein, Lazar, Alexander J., Hwu, Patrick, Hwu, Wen-Jen, Diab, Adi, Glitza, Isabella C., Patel, Sapna P., Woodman, Scott E., Amaria, Rodabe N., Prieto, Victor G., Hu, Jianhua, Sharma, Padmanee, Allison, James P., Chin, Lynda, Zhang, Jianhua, Wargo, Jennifer A., Futreal, P. Andrew
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5819607/
https://ncbi.nlm.nih.gov/pubmed/28251903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aah3560
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