Genomic and immune heterogeneity are associated with differential responses to therapy in melanoma

Appreciation for genomic and immune heterogeneity in cancer has grown though the relationship of these factors to treatment response has not been thoroughly elucidated. To better understand this, we studied a large cohort of melanoma patients treated with targeted therapy or immune checkpoint blocka...

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Published in:NPJ Genom Med
Main Authors: Reuben, Alexandre, Spencer, Christine N., Prieto, Peter A., Gopalakrishnan, Vancheswaran, Reddy, Sangeetha M., Miller, John P., Mao, Xizeng, De Macedo, Mariana Petaccia, Chen, Jiong, Song, Xingzhi, Jiang, Hong, Chen, Pei-Ling, Beird, Hannah C., Garber, Haven R., Roh, Whijae, Wani, Khalida, Chen, Eveline, Haymaker, Cara, Forget, Marie-Andrée, Little, Latasha D., Gumbs, Curtis, Thornton, Rebecca L., Hudgens, Courtney W., Chen, Wei-Shen, Austin-Breneman, Jacob, Sloane, Robert Szczepaniak, Nezi, Luigi, Cogdill, Alexandria P., Bernatchez, Chantale, Roszik, Jason, Hwu, Patrick, Woodman, Scott E., Chin, Lynda, Tawbi, Hussein, Davies, Michael A., Gershenwald, Jeffrey E., Amaria, Rodabe N., Glitza, Isabella C., Diab, Adi, Patel, Sapna P., Hu, Jianhua, Lee, Jeffrey E., Grimm, Elizabeth A., Tetzlaff, Michael T., Lazar, Alexander J., Wistuba, Ignacio I., Clise-Dwyer, Karen, Carter, Brett W., Zhang, Jianhua, Futreal, P. Andrew, Sharma, Padmanee, Allison, James P., Cooper, Zachary A., Wargo, Jennifer A.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557036/
https://ncbi.nlm.nih.gov/pubmed/28819565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41525-017-0013-8
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