Genomic and immune heterogeneity are associated with differential responses to therapy in melanoma

Appreciation for genomic and immune heterogeneity in cancer has grown though the relationship of these factors to treatment response has not been thoroughly elucidated. To better understand this, we studied a large cohort of melanoma patients treated with targeted therapy or immune checkpoint blocka...

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Publicat a:NPJ Genom Med
Autors principals: Reuben, Alexandre, Spencer, Christine N., Prieto, Peter A., Gopalakrishnan, Vancheswaran, Reddy, Sangeetha M., Miller, John P., Mao, Xizeng, De Macedo, Mariana Petaccia, Chen, Jiong, Song, Xingzhi, Jiang, Hong, Chen, Pei-Ling, Beird, Hannah C., Garber, Haven R., Roh, Whijae, Wani, Khalida, Chen, Eveline, Haymaker, Cara, Forget, Marie-Andrée, Little, Latasha D., Gumbs, Curtis, Thornton, Rebecca L., Hudgens, Courtney W., Chen, Wei-Shen, Austin-Breneman, Jacob, Sloane, Robert Szczepaniak, Nezi, Luigi, Cogdill, Alexandria P., Bernatchez, Chantale, Roszik, Jason, Hwu, Patrick, Woodman, Scott E., Chin, Lynda, Tawbi, Hussein, Davies, Michael A., Gershenwald, Jeffrey E., Amaria, Rodabe N., Glitza, Isabella C., Diab, Adi, Patel, Sapna P., Hu, Jianhua, Lee, Jeffrey E., Grimm, Elizabeth A., Tetzlaff, Michael T., Lazar, Alexander J., Wistuba, Ignacio I., Clise-Dwyer, Karen, Carter, Brett W., Zhang, Jianhua, Futreal, P. Andrew, Sharma, Padmanee, Allison, James P., Cooper, Zachary A., Wargo, Jennifer A.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557036/
https://ncbi.nlm.nih.gov/pubmed/28819565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41525-017-0013-8
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