Age- and strain-related aberrant Ca(2+) release is associated with sudden cardiac death in the ACTC E99K mouse model of hypertrophic cardiomyopathy

Patients with hypertrophic cardiomyopathy, particularly young adults, can die from arrhythmia, but the mechanism underlying abnormal rhythm formation remains unknown. C57Bl6 × CBA/Ca mice carrying a cardiac actin (ACTC) E99K (Glu99Lys) mutation reproduce many aspects of human hypertrophic cardiomyop...

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Detalhes bibliográficos
Publicado no:Am J Physiol Heart Circ Physiol
Main Authors: Rowlands, Christina T., Owen, Thomas, Lawal, Saheed, Cao, Shuangyi, Pandey, Samata S., Yang, Hsiang-Yu, Song, Weihua, Wilkinson, Ross, Alvarez-Laviada, Anita, Gehmlich, Katja, Marston, Steven B., MacLeod, Kenneth T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5814650/
https://ncbi.nlm.nih.gov/pubmed/28887330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00244.2017
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