Molecular Mechanism of the E99K Mutation in Cardiac Actin (ACTC Gene) That Causes Apical Hypertrophy in Man and Mouse

We generated a transgenic mouse model expressing the apical hypertrophic cardiomyopathy-causing mutation ACTC E99K at 50% of total heart actin and compared it with actin from patients carrying the same mutation. The actin mutation caused a higher Ca(2+) sensitivity in reconstituted thin filaments me...

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Bibliografiske detaljer
Main Authors: Song, Weihua, Dyer, Emma, Stuckey, Daniel J., Copeland, O'Neal, Leung, Man-Ching, Bayliss, Christopher, Messer, Andrew, Wilkinson, Ross, Tremoleda, Jordi Lopez, Schneider, Michael D., Harding, Sian E., Redwood, Charles S., Clarke, Kieran, Nowak, Kristen, Monserrat, Lorenzo, Wells, Dominic, Marston, Steven B.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149350/
https://ncbi.nlm.nih.gov/pubmed/21622575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.252320
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