Age- and strain-related aberrant Ca(2+) release is associated with sudden cardiac death in the ACTC E99K mouse model of hypertrophic cardiomyopathy

Patients with hypertrophic cardiomyopathy, particularly young adults, can die from arrhythmia, but the mechanism underlying abnormal rhythm formation remains unknown. C57Bl6 × CBA/Ca mice carrying a cardiac actin (ACTC) E99K (Glu99Lys) mutation reproduce many aspects of human hypertrophic cardiomyop...

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Vydáno v:Am J Physiol Heart Circ Physiol
Hlavní autoři: Rowlands, Christina T., Owen, Thomas, Lawal, Saheed, Cao, Shuangyi, Pandey, Samata S., Yang, Hsiang-Yu, Song, Weihua, Wilkinson, Ross, Alvarez-Laviada, Anita, Gehmlich, Katja, Marston, Steven B., MacLeod, Kenneth T.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5814650/
https://ncbi.nlm.nih.gov/pubmed/28887330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00244.2017
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