Mechanical and energetic properties of papillary muscle from ACTC E99K transgenic mouse models of hypertrophic cardiomyopathy

We compared the contractile performance of papillary muscle from a mouse model of hypertrophic cardiomyopathy [α-cardiac actin (ACTC) E99K mutation] with nontransgenic (non-TG) littermates. In isometric twitches, ACTC E99K papillary muscle produced three to four times greater force than non-TG muscl...

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Autores principales: Song, Weihua, Vikhorev, Petr G., Kashyap, Mavin N., Rowlands, Christina, Ferenczi, Michael A., Woledge, Roger C., MacLeod, Kenneth, Marston, Steven, Curtin, Nancy A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2013
Materias:
Muscle Mechanics and Ventricular Function
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680724/
https://ncbi.nlm.nih.gov/pubmed/23604709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00951.2012
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