The Dilated Cardiomyopathy-Causing Mutation ACTC E361G in Cardiac Muscle Myofibrils Specifically Abolishes Modulation of Ca(2+) Regulation by Phosphorylation of Troponin I

Phosphorylation of troponin I by protein kinase A (PKA) reduces Ca(2+) sensitivity and increases the rate of Ca(2+) release from troponin C and the rate of relaxation in cardiac muscle. In vitro experiments indicate that mutations that cause dilated cardiomyopathy (DCM) uncouple this modulation, but...

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Publicat a:Biophys J
Autors principals: Vikhorev, Petr G., Song, Weihua, Wilkinson, Ross, Copeland, O’Neal, Messer, Andrew E., Ferenczi, Michael A., Marston, Steven B.
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2014
Matèries:
Molecular Machines, Motors and Nanoscale Biophysics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4241448/
https://ncbi.nlm.nih.gov/pubmed/25418306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.10.024
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