Age- and strain-related aberrant Ca(2+) release is associated with sudden cardiac death in the ACTC E99K mouse model of hypertrophic cardiomyopathy

Patients with hypertrophic cardiomyopathy, particularly young adults, can die from arrhythmia, but the mechanism underlying abnormal rhythm formation remains unknown. C57Bl6 × CBA/Ca mice carrying a cardiac actin (ACTC) E99K (Glu99Lys) mutation reproduce many aspects of human hypertrophic cardiomyop...

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Publicado en:Am J Physiol Heart Circ Physiol
Autores principales: Rowlands, Christina T., Owen, Thomas, Lawal, Saheed, Cao, Shuangyi, Pandey, Samata S., Yang, Hsiang-Yu, Song, Weihua, Wilkinson, Ross, Alvarez-Laviada, Anita, Gehmlich, Katja, Marston, Steven B., MacLeod, Kenneth T.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2017
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5814650/
https://ncbi.nlm.nih.gov/pubmed/28887330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00244.2017
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