Investigating the role of uncoupling of troponin I phosphorylation from changes in myofibrillar Ca(2+)-sensitivity in the pathogenesis of cardiomyopathy

Por Messer, Andrew E., Marston, Steven B.
Publicado em 2014

'(De-)sensitization' vs. 'Uncoupling': what drives cardiomyopathies in the thin filament? Reply

Por Marston, Steven, Messer, Andrew, Papadaki, Maria
Publicado no Cardiovasc Res (2015)

Uncoupling of myofilament Ca(2+)-sensitivity from troponin I phosphorylation by mutations can be reversed by Epigallocatechin-3-Gallate

Por Papadaki, Maria, Vikhorev, Petr G., Marston, Steven B., Messer, Andrew E.
Publicado no Cardiovasc Res (2015)

Development of apical hypertrophic cardiomyopathy with age in a transgenic mouse model carrying the cardiac actin E99K

Por Wang, Li, Bai, Fan, Zhang, Qing, Song, Weihua, Messer, Andrew, Kawai, Masataka
Publicado no J Muscle Res Cell Motil (2018)

Myopathy-inducing mutation H40Y in ACTA1 hampers actin filament structure and function

Por Chan, Chun, Fan, Jun, Messer, Andrew E., Marston, Steve B., Iwamoto, Hiroyuki, Ochala, Julien
Publicado no Biochim Biophys Acta (2016)

Z-band Alternatively Spliced PDZ Motif Protein (ZASP) Is the Major O-Linked β-N-Acetylglucosamine-substituted Protein in Human Heart Myofibrils

Por Leung, Man-Ching, Hitchen, Paul G., Ward, Douglas G., Messer, Andrew E., Marston, Steven B.
Publicado em 2013

Investigations into the Sarcomeric Protein and Ca(2+)-Regulation Abnormalities Underlying Hypertrophic Cardiomyopathy in Cats (Felix catus)

Por Messer, Andrew E., Chan, Jasmine, Daley, Alex, Copeland, O'Neal, Marston, Steven B., Connolly, David J.
Publicado no Front Physiol (2017)

The Dilated Cardiomyopathy-Causing Mutation ACTC E361G in Cardiac Muscle Myofibrils Specifically Abolishes Modulation of Ca(2+) Regulation by Phosphorylation of Troponin I

Por Vikhorev, Petr G., Song, Weihua, Wilkinson, Ross, Copeland, O’Neal, Messer, Andrew E., Ferenczi, Michael A., Marston, Steven B.
Publicado no Biophys J (2014)

Molecular Defects in Cardiac Myofilament Ca(2+)-Regulation Due to Cardiomyopathy-Linked Mutations Can Be Reversed by Small Molecules Binding to Troponin

Por Sheehan, Alice, Messer, Andrew E., Papadaki, Maria, Choudhry, Afnan, Kren, Vladimír, Biedermann, David, Blagg, Brian, Khandelwal, Anuj, Marston, Steven B.
Publicado no Front Physiol (2018)

Mutations in repeating structural motifs of tropomyosin cause gain of function in skeletal muscle myopathy patients

Por Marston, Steven, Memo, Massimiliano, Messer, Andrew, Papadaki, Maria, Nowak, Kristen, McNamara, Elyshia, Ong, Royston, El-Mezgueldi, Mohammed, Li, Xiaochuan, Lehman, William
Publicado em 2013

OBSCN Mutations Associated with Dilated Cardiomyopathy and Haploinsufficiency

Por Marston, Steven, Montgiraud, Cecile, Munster, Alex B., Copeland, O’Neal, Choi, Onjee, dos Remedios, Cristobal, Messer, Andrew E., Ehler, Elisabeth, Knöll, Ralph
Publicado no PLoS One (2015)

Mutations in troponin T associated with Hypertrophic Cardiomyopathy increase Ca(2+)-sensitivity and suppress the modulation of Ca(2+)-sensitivity by troponin I phosphorylation()

Por Messer, Andrew E., Bayliss, Christopher R., El-Mezgueldi, Mohammed, Redwood, Charles S., Ward, Douglas G., Leung, Man-Ching, Papadaki, Maria, dos Remedios, Cristobal, Marston, Steven B.
Publicado no Arch Biochem Biophys (2016)

The molecular phenotype of human cardiac myosin associated with hypertrophic obstructive cardiomyopathy

Por Jacques, Adam M., Briceno, Natalia, Messer, Andrew E., Gallon, Clare E., Jalilzadeh, Shapour, Garcia, Edwin, Kikonda-Kanda, Gaelle, Goddard, Jennifer, Harding, Sian E., Watkins, Hugh, Esteban, M. Tomé, Tsang, Victor T., McKenna, William J., Marston, Steven B.
Publicado em 2008

Molecular Mechanism of the E99K Mutation in Cardiac Actin (ACTC Gene) That Causes Apical Hypertrophy in Man and Mouse

Por Song, Weihua, Dyer, Emma, Stuckey, Daniel J., Copeland, O'Neal, Leung, Man-Ching, Bayliss, Christopher, Messer, Andrew, Wilkinson, Ross, Tremoleda, Jordi Lopez, Schneider, Michael D., Harding, Sian E., Redwood, Charles S., Clarke, Kieran, Nowak, Kristen, Monserrat, Lorenzo, Wells, Dominic, Marston, Steven B.
Publicado em 2011

Abnormal contractility in human heart myofibrils from patients with dilated cardiomyopathy due to mutations in TTN and contractile protein genes

Por Vikhorev, Petr G., Smoktunowicz, Natalia, Munster, Alex B., Copeland, O’Neal, Kostin, Sawa, Montgiraud, Cecile, Messer, Andrew E., Toliat, Mohammad R., Li, Amy, dos Remedios, Cristobal G., Lal, Sean, Blair, Cheavar A., Campbell, Kenneth S., Guglin, Maya, Richter, Manfred, Knöll, Ralph, Marston, Steven B.
Publicado no Sci Rep (2017)