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Uncoupling of myofilament Ca(2+)-sensitivity from troponin I phosphorylation by mutations can be reversed by Epigallocatechin-3-Gallate
AIMS: Heart muscle contraction is regulated via the β-adrenergic response that leads to phosphorylation of Troponin I (TnI) at Ser22/23, which changes the Ca(2+)-sensitivity of the cardiac myofilament. Mutations in thin filament proteins that cause Dilated Cardiomyopathy (DCM) and some mutations tha...
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| Publicado no: | Cardiovasc Res |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4905512/ https://ncbi.nlm.nih.gov/pubmed/26109583 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvv181 |
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