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Uncoupling of myofilament Ca(2+)-sensitivity from troponin I phosphorylation by mutations can be reversed by Epigallocatechin-3-Gallate

AIMS: Heart muscle contraction is regulated via the β-adrenergic response that leads to phosphorylation of Troponin I (TnI) at Ser22/23, which changes the Ca(2+)-sensitivity of the cardiac myofilament. Mutations in thin filament proteins that cause Dilated Cardiomyopathy (DCM) and some mutations tha...

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Bibliografiska uppgifter
I publikationen:Cardiovasc Res
Huvudupphovsmän: Papadaki, Maria, Vikhorev, Petr G., Marston, Steven B., Messer, Andrew E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905512/
https://ncbi.nlm.nih.gov/pubmed/26109583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvv181
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