Molecular Defects in Cardiac Myofilament Ca(2+)-Regulation Due to Cardiomyopathy-Linked Mutations Can Be Reversed by Small Molecules Binding to Troponin

The inherited cardiomyopathies, hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) are relatively common, potentially life-threatening and currently untreatable. Mutations are often in the contractile proteins of cardiac muscle and cause abnormal Ca(2+) regulation via troponin. HCM i...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Front Physiol
Autores principales: Sheehan, Alice, Messer, Andrew E., Papadaki, Maria, Choudhry, Afnan, Kren, Vladimír, Biedermann, David, Blagg, Brian, Khandelwal, Anuj, Marston, Steven B.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2018
Materias:
Physiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881522/
https://ncbi.nlm.nih.gov/pubmed/29636697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.00243
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares