Mutations in troponin T associated with Hypertrophic Cardiomyopathy increase Ca(2+)-sensitivity and suppress the modulation of Ca(2+)-sensitivity by troponin I phosphorylation()

We investigated the effect of 7 Hypertrophic Cardiomyopathy (HCM)-causing mutations in troponin T (TnT) on troponin function in thin filaments reconstituted with actin and human cardiac tropomyosin. We used the quantitative in vitro motility assay to study Ca(2+)-regulation of unloaded movement and...

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Publicado no:Arch Biochem Biophys
Main Authors: Messer, Andrew E., Bayliss, Christopher R., El-Mezgueldi, Mohammed, Redwood, Charles S., Ward, Douglas G., Leung, Man-Ching, Papadaki, Maria, dos Remedios, Cristobal, Marston, Steven B.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4909753/
https://ncbi.nlm.nih.gov/pubmed/27036851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2016.03.027
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