Effect of Troponin I Ser23/24 Phosphorylation on Ca(2+)-Sensitivity in Human Myocardium Depends on the Phosphorylation Background

Protein kinase A (PKA)-mediated phosphorylation of Ser23/24 of cardiac troponin I (cTnI) causes a reduction in Ca(2+)-sensitivity of force development. This study aimed to determine whether the PKA-induced modulation of the Ca(2+)-sensitivity is solely due to cTnI phosphorylation or depends on the p...

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Detalhes bibliográficos
Main Authors: Kooij, Viola, Saes, Martina, Jaquet, Kornelia, Zaremba, Ruud, Foster, D. Brian, Murphy, Anne M., Remedios, Cris dos, van der Velden, Jolanda, Stienen, Ger J.M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854313/
https://ncbi.nlm.nih.gov/pubmed/20079747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2010.01.002
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