Impact of site-specific phosphorylation of protein kinase A sites Ser(23) and Ser(24) of cardiac troponin I in human cardiomyocytes

PKA-mediated phosphorylation of contractile proteins upon β-adrenergic stimulation plays an important role in the regulation of cardiac performance. Phosphorylation of the PKA sites (Ser(23)/Ser(24)) of cardiac troponin (cTn)I results in a decrease in myofilament Ca(2+) sensitivity and an increase i...

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Bibliografiset tiedot
Päätekijät: Wijnker, Paul J. M., Foster, D. Brian, Tsao, Allison L., Frazier, Aisha H., dos Remedios, Cristobal G., Murphy, Anne M., Stienen, Ger J. M., van der Velden, Jolanda
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Physiological Society 2013
Aiheet:
Muscle Mechanics and Ventricular Function
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543672/
https://ncbi.nlm.nih.gov/pubmed/23144315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00498.2012
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