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Impact of site-specific phosphorylation of protein kinase A sites Ser(23) and Ser(24) of cardiac troponin I in human cardiomyocytes
PKA-mediated phosphorylation of contractile proteins upon β-adrenergic stimulation plays an important role in the regulation of cardiac performance. Phosphorylation of the PKA sites (Ser(23)/Ser(24)) of cardiac troponin (cTn)I results in a decrease in myofilament Ca(2+) sensitivity and an increase i...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3543672/ https://ncbi.nlm.nih.gov/pubmed/23144315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00498.2012 |
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