Phosphorylation of protein kinase C sites Ser42/44 decreases Ca(2+)-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytes

Protein kinase C (PKC)-mediated phosphorylation of troponin I (cTnI) at Ser42/44 is increased in heart failure. While studies in rodents demonstrated that PKC-mediated Ser42/44 phosphorylation decreases maximal force and ATPase activity, PKC incubation of human cardiomyocytes did not affect maximal...

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Main Authors: Wijnker, Paul J.M., Sequeira, Vasco, Witjas-Paalberends, E. Rosalie, Foster, D. Brian, dos Remedios, Cristobal G., Murphy, Anne M., Stienen, Ger J.M., van der Velden, Jolanda
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121669/
https://ncbi.nlm.nih.gov/pubmed/24814372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2014.04.017
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