A Novel Phosphorylation Site, Serine 199, in the C-Terminus of Cardiac Troponin I Regulates Calcium Sensitivity and Susceptibility to Calpain-Induced Proteolysis

Phosphorylation of cardiac troponin I (cTnI) by protein kinase C (PKC) is implicated in cardiac dysfunction. Recently, Serine 199 (Ser199) was identified as a target for PKC phosphorylation and increased Ser199 phosphorylation occurs in end-stage failing compared with non-failing human myocardium. T...

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Publicat a:J Mol Cell Cardiol
Autors principals: Wijnker, Paul J.M., Li, Yuejin, Zhang, Pingbo, Foster, D. Brian, dos Remedios, Cris, Van Eyk, Jennifer E., Stienen, Ger J.M., Murphy, Anne M., van der Velden, Jolanda
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405491/
https://ncbi.nlm.nih.gov/pubmed/25771144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2015.03.006
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