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Cardiac Troponin I Tyrosine 26 Phosphorylation Decreases Myofilament Ca(2+) Sensitivity and Accelerates Deactivation

Troponin I (TnI), the inhibitory subunit of the troponin complex, can be phosphorylated as a key regulatory mechanism to alter the calcium regulation of contraction. Recent work has identified phosphorylation of TnI Tyr-26 in the human heart with unknown functional effects. We hypothesized that TnI...

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Detalhes bibliográficos
Publicado no:J Mol Cell Cardiol
Main Authors: Salhi, Hussam E., Walton, Shane D., Hassel, Nathan C., Brundage, Elizabeth A., de Tombe, Pieter P., Janssen, Paul M.L., Davis, Jonathan P., Biesiadecki, Brandon J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250312/
https://ncbi.nlm.nih.gov/pubmed/25252176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2014.09.013
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