Metabolic Profiling of CB1 Neutral Antagonists

PIMSR is among the first neutral antagonists for the CB1R and was demonstrated pharmacologically to bind to the CB1R, yet not alter calcium flux. It was further shown computationally to be able to stabilize both the active and inactive states of CB1R revealing the molecular interactions that mechani...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Methods Enzymol
Main Authors: Seltzman, Herbert H., Maitra, Rangan, Bortoff, Katharine, Henson, Jay, Reggio, Patricia H., Wesley, Daniel, Tam, Joseph
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5802864/
https://ncbi.nlm.nih.gov/pubmed/28750803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/bs.mie.2017.06.025
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