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Pyrazole Antagonists of the CB1 receptor with reduced brain penetration
Type 1 cannabinoid receptor (CB1) antagonists might be useful for treating obesity, liver disease, metabolic syndrome, and dyslipidemias. Unfortunately, inhibition of CB1 in the central nervous system (CNS) produces adverse effects, including depression, anxiety and suicidal ideation in some patient...
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| Publicado no: | Bioorg Med Chem |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4762035/ https://ncbi.nlm.nih.gov/pubmed/26827137 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.01.033 |
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