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Design and Synthesis of Cannabinoid Receptor 1 Antagonists for Peripheral Selectivity

Antagonists of cannabinoid receptor 1 (CB1) have potential for the treatment of several diseases such as obesity, liver disease and diabetes. Recently, development of several CB1 antagonists was halted due to adverse central nervous system (CNS) related side effects observed with rimonabant, the fir...

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Detalhes bibliográficos
Main Authors: Fulp, Alan, Bortoff, Katherine, Seltzman, Herbert, Zhang, Yanan, Mathews, James, Snyder, Rodney, Fennell, Tim, Maitra, Rangan
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3319116/
https://ncbi.nlm.nih.gov/pubmed/22372835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201731z
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