Blocking Alcoholic Steatosis in Mice with a Peripherally Restricted Purine Antagonist of the Type 1 Cannabinoid Receptor

Type 1 cannabinoid receptor (CB1) antagonists have demonstrated promise for the treatment of obesity, liver disease, metabolic syndrome, and dyslipidemias. However, the inhibition of CB1 receptors in the central nervous system can produce adverse effects, including depression, anxiety, and suicidal...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Amato, George S., Manke, Amruta, Harris, Danni L., Wiethe, Robert W., Vasukuttan, Vineetha, Snyder, Rodney W., Lefever, Timothy W., Cortes, Ricardo, Zhang, Yanan, Wang, Shaobin, Runyon, Scott P., Maitra, Rangan
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7607848/
https://ncbi.nlm.nih.gov/pubmed/29688015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01820
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