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Synthesis and pharmacological characterization of functionalized 6-piperazin-1-yl-purines as cannabinoid receptor 1 (CB1) inverse agonists
Antagonists of peripheral type 1 cannabinoid receptors (CB1) may have utility in the treatment of obesity, liver disease, metabolic syndrome and dyslipidemias. We have targeted the purine otenabant (1) analogues for this purpose. The non-tissue selective CB1 antagonist rimonabant (2) was approved as...
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| Publicado no: | Bioorg Med Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6129194/ https://ncbi.nlm.nih.gov/pubmed/30077609 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2018.07.043 |
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