Blocking Alcoholic Steatosis in Mice with a Peripherally Restricted Purine Antagonist of the Type 1 Cannabinoid Receptor

Type 1 cannabinoid receptor (CB1) antagonists have demonstrated promise for the treatment of obesity, liver disease, metabolic syndrome, and dyslipidemias. However, the inhibition of CB1 receptors in the central nervous system can produce adverse effects, including depression, anxiety, and suicidal...

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Publicado en:J Med Chem
Autores principales: Amato, George S., Manke, Amruta, Harris, Danni L., Wiethe, Robert W., Vasukuttan, Vineetha, Snyder, Rodney W., Lefever, Timothy W., Cortes, Ricardo, Zhang, Yanan, Wang, Shaobin, Runyon, Scott P., Maitra, Rangan
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7607848/
https://ncbi.nlm.nih.gov/pubmed/29688015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01820
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