Pyrazole Antagonists of the CB1 receptor with reduced brain penetration

Type 1 cannabinoid receptor (CB1) antagonists might be useful for treating obesity, liver disease, metabolic syndrome, and dyslipidemias. Unfortunately, inhibition of CB1 in the central nervous system (CNS) produces adverse effects, including depression, anxiety and suicidal ideation in some patient...

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Bibliografiska uppgifter
I publikationen:Bioorg Med Chem
Huvudupphovsmän: Fulp, Alan, Zhang, Yanan, Bortoff, Katherine, Seltzman, Herbert, Snyder, Rodney, Wiethe, Robert, Amato, George, Maitra, Rangan
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4762035/
https://ncbi.nlm.nih.gov/pubmed/26827137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.01.033
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