Suppression of homology-dependent DNA double-strand break repair induces PARP inhibitor sensitivity in VHL-deficient human renal cell carcinoma

The von Hippel-Lindau (VHL) tumor suppressor gene is inactivated in the vast majority of human clear cell renal carcinomas. The pathogenesis of VHL loss is currently best understood to occur through stabilization of the hypoxia-inducible factors, activation of hypoxia-induced signaling pathways, and...

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Publicado en:Oncotarget
Autores principales: Scanlon, Susan E., Hegan, Denise C., Sulkowski, Parker L., Glazer, Peter M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5797003/
https://ncbi.nlm.nih.gov/pubmed/29435132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23470
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