Suppression of homology-dependent DNA double-strand break repair induces PARP inhibitor sensitivity in VHL-deficient human renal cell carcinoma

The von Hippel-Lindau (VHL) tumor suppressor gene is inactivated in the vast majority of human clear cell renal carcinomas. The pathogenesis of VHL loss is currently best understood to occur through stabilization of the hypoxia-inducible factors, activation of hypoxia-induced signaling pathways, and...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Scanlon, Susan E., Hegan, Denise C., Sulkowski, Parker L., Glazer, Peter M.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5797003/
https://ncbi.nlm.nih.gov/pubmed/29435132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23470
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