A cell-penetrating antibody inhibits human RAD51 via direct binding

Por Turchick, Audrey, Hegan, Denise C., Jensen, Ryan B., Glazer, Peter M.
Publicado no Nucleic Acids Res (2017)

Suppression of homology-dependent DNA double-strand break repair induces PARP inhibitor sensitivity in VHL-deficient human renal cell carcinoma

Por Scanlon, Susan E., Hegan, Denise C., Sulkowski, Parker L., Glazer, Peter M.
Publicado no Oncotarget (2017)

Targeted Gene Modification of Hematopoietic Progenitor Cells in Mice Following Systemic Administration of a PNA-peptide Conjugate

Por Rogers, Faye A, Lin, Sharon S, Hegan, Denise C, Krause, Diane S, Glazer, Peter M
Publicado em 2012

Hypoxia and DNA Repair

Por Glazer, Peter M., Hegan, Denise C., Lu, Yuhong, Czochor, Jennifer, Scanlon, Susan E.
Publicado em 2013

Mechanism of Action Studies of Lomaiviticin A and the Monomeric Lomaiviticin Aglycon. Selective and Potent Activity Toward DNA Double-Strand Break Repair-Deficient Cell Lines

Por Colis, Laureen C., Hegan, Denise C., Kaneko, Miho, Glazer, Peter M., Herzon, Seth B.
Publicado no J Am Chem Soc (2015)

Nickel induces transcriptional down-regulation of DNA repair pathways in tumorigenic and non-tumorigenic lung cells

Por Scanlon, Susan E, Scanlon, Christine D, Hegan, Denise C, Sulkowski, Parker L, Glazer, Peter M
Publicado no Carcinogenesis (2017)

The cytotoxicity of (–)-lomaiviticin A arises from induction of double-strand breaks in DNA

Por Colis, Laureen C., Woo, Christina M., Hegan, Denise C., Li, Zhenwu, Glazer, Peter M., Herzon, Seth B.
Publicado em 2014

Targeting cancer with a lupus autoantibody

Por Hansen, James E., Chan, Grace, Liu, Yanfeng, Hegan, Denise C., Dalal, Shibani, Dray, Eloise, Kwon, Youngho, Xu, Yuanyuan, Xu, Xiaohua, Peterson-Roth, Elizabeth, Geiger, Erik, Liu, Yilun, Gera, Joseph, Sweasy, Joann B., Sung, Patrick, Rockwell, Sara, Nishimura, Robert N., Weisbart, Richard H., Glazer, Peter M.
Publicado em 2012

2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity

Por Sulkowski, Parker L., Corso, Christopher D., Robinson, Nathaniel D., Scanlon, Susan E., Purshouse, Karin R., Bai, Hanwen, Liu, Yanfeng, Sundaram, Ranjini K., Hegan, Denise C., Fons, Nathan R., Breuer, Gregory A., Song, Yuanbin, Mishra-Gorur, Ketu, De Feyter, Henk, de Graaf, Robin A., Surovtseva, Yulia V., Kachman, Maureen, Halene, Stephanie, Günel, Murat, Glazer, Peter M., Bindra, Ranjit S.
Publicado no Sci Transl Med (2017)