2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity

2-Hydroxyglutarate (2HG) exists as two enantiomers, (R)-2HG and (S)-2HG, and both are implicated in tumor progression via their inhibitory effects on α-ketoglutarate (αKG)-dependent dioxygenases. The former is an oncometabolite that is induced by the neomorphic activity conferred by isocitrate dehyd...

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Bibliografski detalji
Izdano u:Sci Transl Med
Glavni autori: Sulkowski, Parker L., Corso, Christopher D., Robinson, Nathaniel D., Scanlon, Susan E., Purshouse, Karin R., Bai, Hanwen, Liu, Yanfeng, Sundaram, Ranjini K., Hegan, Denise C., Fons, Nathan R., Breuer, Gregory A., Song, Yuanbin, Mishra-Gorur, Ketu, De Feyter, Henk, de Graaf, Robin A., Surovtseva, Yulia V., Kachman, Maureen, Halene, Stephanie, Günel, Murat, Glazer, Peter M., Bindra, Ranjit S.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5435119/
https://ncbi.nlm.nih.gov/pubmed/28148839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aal2463
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