Replication Study: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

In 2016, as part of the Reproducibility Project: Cancer Biology, we published a Registered Report (Fiehn et al., 2016), that described how we intended to replicate selected experiments from the paper "The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activ...

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Veröffentlicht in:eLife
Hauptverfasser: Showalter, Megan Reed, Hatakeyama, Jason, Cajka, Tomas, VanderVorst, Kacey, Carraway, Kermit L, Fiehn, Oliver
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2017
Schlagworte:
Biochemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487214/
https://ncbi.nlm.nih.gov/pubmed/28653623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.26030
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