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Structural basis of thalidomide enantiomer binding to cereblon
Thalidomide possesses two optical isomers which have been reported to exhibit different pharmacological and toxicological activities. However, the precise mechanism by which the two isomers exert their different activities remains poorly understood. Here, we present structural and biochemical studie...
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| Publicat a: | Sci Rep |
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| Autors principals: | , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5778007/ https://ncbi.nlm.nih.gov/pubmed/29358579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19202-7 |
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