Thalidomide and its metabolite 5‐hydroxythalidomide induce teratogenicity via the cereblon neosubstrate PLZF

Thalidomide causes teratogenic effects by inducing protein degradation via cereblon (CRBN)‐containing ubiquitin ligase and modification of its substrate specificity. Human P450 cytochromes convert thalidomide into two monohydroxylated metabolites that are considered to contribute to thalidomide effe...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:EMBO J
Auteurs principaux: Yamanaka, Satoshi, Murai, Hidetaka, Saito, Daisuke, Abe, Gembu, Tokunaga, Etsuko, Iwasaki, Takahiro, Takahashi, Hirotaka, Takeda, Hiroyuki, Suzuki, Takayuki, Shibata, Norio, Tamura, Koji, Sawasaki, Tatsuya
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2021
Sujets:
Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7883055/
https://ncbi.nlm.nih.gov/pubmed/33470442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020105375
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires