Thalidomide and its metabolite 5‐hydroxythalidomide induce teratogenicity via the cereblon neosubstrate PLZF

Thalidomide causes teratogenic effects by inducing protein degradation via cereblon (CRBN)‐containing ubiquitin ligase and modification of its substrate specificity. Human P450 cytochromes convert thalidomide into two monohydroxylated metabolites that are considered to contribute to thalidomide effe...

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發表在:EMBO J
Main Authors: Yamanaka, Satoshi, Murai, Hidetaka, Saito, Daisuke, Abe, Gembu, Tokunaga, Etsuko, Iwasaki, Takahiro, Takahashi, Hirotaka, Takeda, Hiroyuki, Suzuki, Takayuki, Shibata, Norio, Tamura, Koji, Sawasaki, Tatsuya
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2021
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Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7883055/
https://ncbi.nlm.nih.gov/pubmed/33470442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020105375
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