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Structural basis of thalidomide enantiomer binding to cereblon
Thalidomide possesses two optical isomers which have been reported to exhibit different pharmacological and toxicological activities. However, the precise mechanism by which the two isomers exert their different activities remains poorly understood. Here, we present structural and biochemical studie...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5778007/ https://ncbi.nlm.nih.gov/pubmed/29358579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19202-7 |
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