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Understanding the Thalidomide Chirality in Biological Processes by the Self-disproportionation of Enantiomers
Twenty years after the thalidomide disaster in the late 1950s, Blaschke et al. reported that only the (S)-enantiomer of thalidomide is teratogenic. However, other work has shown that the enantiomers of thalidomide interconvert in vivo, which begs the question: why is teratogen activity not observed...
Gorde:
| Argitaratua izan da: | Sci Rep |
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| Egile Nagusiak: | , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Nature Publishing Group UK
2018
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6244226/ https://ncbi.nlm.nih.gov/pubmed/30459439 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-35457-6 |
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