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Structural basis of thalidomide enantiomer binding to cereblon
Thalidomide possesses two optical isomers which have been reported to exhibit different pharmacological and toxicological activities. However, the precise mechanism by which the two isomers exert their different activities remains poorly understood. Here, we present structural and biochemical studie...
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| Veröffentlicht in: | Sci Rep |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5778007/ https://ncbi.nlm.nih.gov/pubmed/29358579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19202-7 |
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