Unbiased mapping of cereblon neosubstrate landscape by high-throughput proteomics
Abstract Molecular glue degraders (MGDs) are small molecules that co-opt the ubiquitin-proteasome system to induce degradation of target proteins, including those considered undruggable. Their discovery remains challenging due to the lack of rational design strategies and limited throughput of unbia...
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| Главные авторы: | , , , , , , , , , , , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Portfolio
2025-08-01
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| Серии: | Nature Communications |
| Online-ссылка: | https://doi.org/10.1038/s41467-025-62829-0 |
| Метки: |
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