Unbiased mapping of cereblon neosubstrate landscape by high-throughput proteomics
Abstract Molecular glue degraders (MGDs) are small molecules that co-opt the ubiquitin-proteasome system to induce degradation of target proteins, including those considered undruggable. Their discovery remains challenging due to the lack of rational design strategies and limited throughput of unbia...
সংরক্ষণ করুন:
| প্রধান লেখক: | , , , , , , , , , , , , , , , , , , , , |
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| বিন্যাস: | Artigo |
| ভাষা: | Inglês |
| প্রকাশিত: |
Nature Portfolio
2025-08-01
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| মালা: | Nature Communications |
| অনলাইন ব্যবহার করুন: | https://doi.org/10.1038/s41467-025-62829-0 |
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