Nanoscale Assembly of High-Mobility Group AT-Hook 2 Protein with DNA Replication Fork

High mobility group AT-hook 2 (HMGA2) protein is composed of three AT-hook domains. HMGA2 expresses at high levels in both embryonic stem cells and cancer cells, where it interacts with and stabilizes replication forks (RFs), resulting in elevated cell proliferation rates. In this study, we demonstr...

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Vydáno v:Biophys J
Hlavní autoři: Krahn, Natalie, Meier, Markus, To, Vu, Booy, Evan P., McEleney, Kevin, O’Neil, Joe D., McKenna, Sean A., Patel, Trushar R., Stetefeld, Jörg
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2017
Témata:
Nucleic Acids and Genome Biophysics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5771026/
https://ncbi.nlm.nih.gov/pubmed/29262356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.10.026
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