Nanoscale Assembly of High-Mobility Group AT-Hook 2 Protein with DNA Replication Fork

High mobility group AT-hook 2 (HMGA2) protein is composed of three AT-hook domains. HMGA2 expresses at high levels in both embryonic stem cells and cancer cells, where it interacts with and stabilizes replication forks (RFs), resulting in elevated cell proliferation rates. In this study, we demonstr...

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Bibliographic Details
Published in:Biophys J
Main Authors: Krahn, Natalie, Meier, Markus, To, Vu, Booy, Evan P., McEleney, Kevin, O’Neil, Joe D., McKenna, Sean A., Patel, Trushar R., Stetefeld, Jörg
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2017
Subjects:
Nucleic Acids and Genome Biophysics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5771026/
https://ncbi.nlm.nih.gov/pubmed/29262356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.10.026
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