Nanoscale Assembly of High-Mobility Group AT-Hook 2 Protein with DNA Replication Fork

High mobility group AT-hook 2 (HMGA2) protein is composed of three AT-hook domains. HMGA2 expresses at high levels in both embryonic stem cells and cancer cells, where it interacts with and stabilizes replication forks (RFs), resulting in elevated cell proliferation rates. In this study, we demonstr...

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Библиографические подробности
Опубликовано в: :Biophys J
Главные авторы: Krahn, Natalie, Meier, Markus, To, Vu, Booy, Evan P., McEleney, Kevin, O’Neil, Joe D., McKenna, Sean A., Patel, Trushar R., Stetefeld, Jörg
Формат: Artigo
Язык:Inglês
Опубликовано: The Biophysical Society 2017
Предметы:
Nucleic Acids and Genome Biophysics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5771026/
https://ncbi.nlm.nih.gov/pubmed/29262356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.10.026
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