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Nanoscale Assembly of High-Mobility Group AT-Hook 2 Protein with DNA Replication Fork

High mobility group AT-hook 2 (HMGA2) protein is composed of three AT-hook domains. HMGA2 expresses at high levels in both embryonic stem cells and cancer cells, where it interacts with and stabilizes replication forks (RFs), resulting in elevated cell proliferation rates. In this study, we demonstr...

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Bibliografiske detaljer
Udgivet i:Biophys J
Main Authors: Krahn, Natalie, Meier, Markus, To, Vu, Booy, Evan P., McEleney, Kevin, O’Neil, Joe D., McKenna, Sean A., Patel, Trushar R., Stetefeld, Jörg
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5771026/
https://ncbi.nlm.nih.gov/pubmed/29262356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.10.026
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