Recognition of viral RNA stem–loops by the tandem double-stranded RNA binding domains of PKR

In humans, the double-stranded RNA (dsRNA)-activated protein kinase (PKR) is expressed in late stages of the innate immune response to viral infection by the interferon pathway. PKR consists of tandem dsRNA binding motifs (dsRBMs) connected via a flexible linker to a Ser/Thr kinase domain. Upon inte...

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Détails bibliographiques
Auteurs principaux: Dzananovic, Edis, Patel, Trushar R., Deo, Soumya, McEleney, Kevin, Stetefeld, Jörg, McKenna, Sean A.
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2013
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677244/
https://ncbi.nlm.nih.gov/pubmed/23329698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.035931.112
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