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Recognition of viral RNA stem–loops by the tandem double-stranded RNA binding domains of PKR
In humans, the double-stranded RNA (dsRNA)-activated protein kinase (PKR) is expressed in late stages of the innate immune response to viral infection by the interferon pathway. PKR consists of tandem dsRNA binding motifs (dsRBMs) connected via a flexible linker to a Ser/Thr kinase domain. Upon inte...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Cold Spring Harbor Laboratory Press
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3677244/ https://ncbi.nlm.nih.gov/pubmed/23329698 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.035931.112 |
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