Polygenic hazard scores in preclinical Alzheimer’s disease

Identifying asymptomatic older individuals at elevated risk for developing Alzheimer’s disease (AD) is of clinical importance. Among 1,081 asymptomatic older adults, a recently validated polygenic hazard score (PHS) significantly predicted time to AD dementia and steeper longitudinal cognitive decli...

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Dades bibliogràfiques
Publicat a:Ann Neurol
Autors principals: Tan, Chin Hong, Hyman, Bradley T., Tan, Jacinth J. X., Hess, Christopher P., Dillon, William P., Schellenberg, Gerard D., Besser, Lilah M., Kukull, Walter A., Kauppi, Karolina, McEvoy, Linda K., Andreassen, Ole A., Dale, Anders M., Fan, Chun Chieh, Desikan, Rahul S.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5758043/
https://ncbi.nlm.nih.gov/pubmed/28940650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.25029
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